Select publications from AROS and Collaborators

Nielsen KB, Kruhøffer M, Holm IE, Jørgensen AL, Nielsen AL. Identification of genes differentially expressed in the embryonic pig cerebral cortex before and after appearance of gyration. BMC Res Notes. 2010 May 5;3:127. PubMed PMID: 20444278; PubMed Central PMCID: PMC2877059.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes. 2010 Feb;59(2):358-74. Epub 2009 Nov 23. PubMed PMID: 19934004; PubMed Central PMCID: PMC2809955

Jorissen RN, Gibbs P, Christie M, Prakash S, Lipton L, Desai J, Kerr D, Aaltonen LA, Arango D, Kruhøffer M, Orntoft TF, Andersen CL, Gruidl M, Kamath VP, Eschrich S, Yeatman TJ, Sieber OM. Metastasis-Associated Gene Expression Changes  Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer. Clin Cancer Res. 2009 Dec 15;15(24):7642-7651. Epub. PubMed PMID: 19996206; PubMed Central PMCID: PMC2920750.

Hollegaard MV, Grauholm J, Børglum A, Nyegaard M, Nørgaard-Pedersen B, Ørntoft T, Mortensen PB, Wiuf C, Mors O, Didriksen M, Thorsen P, Hougaard DM. Genome-wide scans using archived neonatal dried blood spot samples. BMC Genomics. 2009 Jul 4;10:297. PubMed PMID: 19575812; PubMed Central PMCID: PMC2713266.

Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T. IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes. Eur Cytokine Netw. 2009 Jun 1;20(2):81-87. PubMed  PMID: 19541594.

Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sørensen FB, Verspaget HW, Simon R, Kruhøffer M, Aaltonen LA, Laurberg S, Ørntoft TF. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer. 2009 Feb 10;100(3):511-23. Epub 2009 Jan 20. PubMed PMID: 19156145; PubMed Central PMCID: PMC2658541.

 

Kruhøffer M, Voss T, Beller K, Scherer M, Cramer J, Deutschmann T, Homberg C, Schlumpberger M  and Lenz C. Evaluation of the QIAsymphony SP Workstation for Magnetic Particle-Based Nucleic Acid Purification From Different Sample Types for Demanding Downstream Applications. JALA 2010;15:41–51

 

Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sørensen FB, Verspaget HW, Simon R, Kruhøffer M, Aaltonen LA, Laurberg S, Ørntoft TF. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer. 2009 Feb 10;100(3):511-23. Epub 2009 Jan 20. PubMed PMID: 19156145.

 

Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskjøt L, Wiuf C, Sørensen FJ, Kruhøffer M, Laurberg S, Kauppinen S, Ørntoft TF, Andersen CL. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res. 2008 Aug 1;68(15):6416-24. PubMed PMID: 18676867.

Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM,

Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, Orntoft TF. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics. 2008 Jul;7(7):1214-24. Epub 2008 Mar 18. PubMed PMID: 18353764.

Sørensen KD, Borre M, Ørntoft TF, Dyrskjøt L, Tørring N. Chromosomal deletion,

promoter hypermethylation and downregulation of FYN in prostate cancer. Int J Cancer. 2008 Feb 1;122(3):509-19. PubMed PMID: 17943724.

Kruhøffer M, Dyrskjøt L, Voss T, Lindberg RL, Wyrich R, Thykjaer T, Orntoft TF. Isolation of microarray-grade total RNA, microRNA, and DNA from a single PAXgene blood RNA tube. J Mol Diagn. 2007 Sep;9(4):452-8. Epub 2007 Aug 9. PubMed PMID: 17690207; PubMed Central PMCID: PMC1975097.

Als AB, Dyrskjøt L, von der Maase H, Koed K, Mansilla F, Toldbod HE, Jensen JL, Ulhøi BP, Sengeløv L, Jensen KM, Orntoft TF. Emmprin and survivin predict response and survival following cisplatin-containing chemotherapy in patients with advanced bladder cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4407-14. PubMed PMID: 17671123.

Mansilla F, Birkenkamp-Demtroder K, Kruhøffer M, Sørensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW, Orntoft TF. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer. 2007 Jun 18;96(12):1896-903. Epub 2007 May 22. PubMed PMID: 17519897.

Tørring N, Borre M, Sørensen KD, Andersen CL, Wiuf C, Ørntoft TF. Genome-wide

analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br J Cancer. 2007 Feb 12;96(3):499-506. Epub 2007 Jan 23. PubMed PMID: 17245344.

 

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed PMID: 17136093.

Marcheco-Teruel B, Flint TJ, Wikman FP, Torralbas M, González L, Blanco L, Tan Q, Ewald H, Orntoft T, Kruse TA, Børglum AD, Mors O. A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):833-43. PubMed PMID: 16917938.

Enver T, Soneji S, Joshi C, Brown J, Iborra F, Orntoft T, Thykjaer T, Maltby E, Smith K, Dawud RA, Jones M, Matin M, Gokhale P, Draper J, Andrews PW. Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet. 2005 Nov 1;14(21):3129-40. Epub 2005 Sep 13. PubMed PMID: 16159889.

Pallante P, Berlingieri MT, Troncone G, Kruhoffer M, Orntoft TF, Viglietto G, Caleo A, Migliaccio I, Decaussin-Petrucci M, Santoro M, Palombini L, Fusco A. UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas. Br J Cancer. 2005 Aug 22;93(4):464-71. PubMed PMID: 16106252.

Kruhøffer M, Jensen JL, Laiho P, Dyrskjøt L, Salovaara R, Arango D, Birkenkamp-Demtroder K, Sørensen FB, Christensen LL, Buhl L, Mecklin JP, Järvinen H, Thykjaer T, Wikman FP, Bech-Knudsen F, Juhola M, Nupponen NN, Laurberg S, Andersen CL, Aaltonen LA, Ørntoft TF. Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br J Cancer. 2005 Jun20;92(12):2240-8. PubMed PMID: 15956967.

 

Eschrich S, Yang I, Bloom G, Kwong KY, Boulware D, Cantor A, Coppola D, Kruhøffer M, Aaltonen L, Orntoft TF, Quackenbush J, Yeatman TJ. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005 May 20;23(15):3526-35. PubMed PMID: 15908663.

 

Birkenkamp-Demtroder K, Olesen SH, Sorensen FB, Laurberg S, Laiho P, Aaltonen LA, Orntoft TF. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut. 2005 Mar;54(3):374-84.

Ripa RS, Katballe N, Wikman FP, Jager AC, Bernstein I, Orntoft T, Schwartz M, Nielsen FC, Bisgaard ML. Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer. Mutat Res. 2005 Feb 15;570(1):89-96.

Olesen SH, Christensen LL, Sorensen FB, Cabezon T, Laurberg S, Orntoft TF, Birkenkamp-Demtroder K. Human FK506 binding protein 65 is associated with colorectal cancer. Mol Cell Proteomics. 2005 Jan 25; [Epub ahead of print]

Koed K, Wiuf C, Christensen LL, Wikman FP, Zieger K, Moller K, von der Maase H, Orntoft TF. High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Cancer Res. 2005 Jan 1;65(1):34-45.
Torring N, Hansen FD, Sorensen BS, Orntoft TF, Nexo E. Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition. Prostate. 2005 Jan 13; [Epub ahead of print]

Nielsen K, Kruhoffer M, Orntoft T, Sparre T, Wang H, Wollheim C, Jorgensen MC, Nerup J, Karlsen AE.Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. Diabetologia. 2004 Dec 17; [Epub ahead of print].

Karlsen AE, Heding PE, Frobose H, Ronn SG, Kruhoffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1 beta-mediated toxicity through inhibition of multiple nuclear factor-kappa B-regulated proapoptotic pathways. Diabetologia. 2004 Nov;47(11):1998-2011.

Martinez Hoyos J, Fedele M, Battista S, Pentimalli F, Kruhoffer M, Arra C, Orntoft TF, Croce CM, Fusco A. Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation. Cancer Res. 2004 Aug 15;64(16):5728-35.

Hoyos JM, Fedele M, Battista S, Pentimalli F, Kruhøffer M, Arra C, Orntoft TF, Croce CM, Fusco A. Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation. Cancer Res. 2004 Aug 15;64(16):5728-35.

Vermijlen D, Seynaeve C, Luo D, Kruhøffer M, Eizirik DL, Orntoft TF, Wisse E. High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells. Eur J Immunol. 2004 Sep;34(9):2529-40.

Lardon J, De Breuck S, Rooman I, Van Lommel L, Kruhøffer M, Orntoft T, Schuit F, Bouwens L. Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology. 2004 Jun;39(6):1499-507.

Castellone MD, Guarino V, De Falco V, Carlomagno F, Basolo F, Faviana P, Kruhøffer M, Orntoft T, Russell JP, Rothstein JL, Fusco A, Santoro M, Melillo RM. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene. 2004 Aug 5;23(35):5958-67.

Dyrskjot L, Kruhøffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K,Orntoft TF. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res. 2004 Jun 1;64(11):4040-8.

Castellone MD, Celetti A, Guarino V, Cirafici AM, Basolo F, Giannini R, Medico E, Kruhøffer M, Orntoft TF, Curcio F, Fusco A, Melillo RM, Santoro M. Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. Oncogene. 2004 Mar 18;23(12):2188-96.

Rasschaert J, Liu D, Kutlu B, Cardozo AK, Kruhøffer M, Orntoft TF, Eizirik DL. Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells. Diabetologia. 2003 Dec;46(12):1641-57. Epub 2003 Nov 05.

Cardozo AK, Berthou L, Kruhøffer M, Orntoft T, Nicolls MR, Eizirik DL. Gene microarray study corroborates proteomic findings in rodent islet cells. J Proteome Res. 2003 Sep-Oct;2(5):553-5.

Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Orntoft T, Eizirik DL. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes. 2003 Nov;52(11):2701-19.

Moraes R, Blondet A, Birkenkamp-Demtroeder K, Tirard J, Orntoft T, Gertler
A, Durand P, Naville D, Begeot M.
Study of the alteration of gene expression in adipose tissue of diet-induced obesity (DIO) mice by microarray and RT-PCR analyses.
Endocrinology. 2003 Aug 13 [Epub ahead of print]

Frederiksen CM, Aaboe M, Dyrskjot L, Laurberg S, Wolf H, Orntoft TF,
Kruhoffer M.
Technical evaluation of cDNA microarrays.
APMIS Suppl. 2003;(109):96-101.

Nielsen K, Birkenkamp-Demtroder K, Ehlers N, Orntoft TF.
Identification of differentially expressed genes in keratoconus epithelium
analyzed on microarrays.
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2466-76.

Frederiksen CM, Knudsen S, Laurberg S, Orntoft TF.
Classification of Dukes' B and C colorectal cancers using expression arrays.
J Cancer Res Clin Oncol. 2003 May;129(5):263-71. Epub 2003 May 15.

Jeppesen PB, Gregersen S, Rolfsen SE, Jepsen M, Colombo M, Agger A, Xiao J,
Kruhoffer M, Orntoft T, Hermansen K.
Antihyperglycemic and blood pressure-reducing effects of stevioside in the
diabetic Goto-Kakizaki rat.
Metabolism. 2003 Mar;52(3):372-8.

Vallat L, Magdelenat H, Merle-Beral H, Masdehors P, Potocki de Montalk G,
Davi F, Kruhoffer M, Sabatier L, Orntoft TF, Delic J.
The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA
microarrays.
Blood. 2003 Jun 1;101(11):4598-606. Epub 2003 Feb 13.

Dyrskjot L, Thykjaer T, Kruhoffer M, Jensen JL, Marcussen N,
Hamilton-Dutoit S, Wolf H, Orntoft TF.
Identifying distinct classes of bladder carcinoma using microarrays.
Nat Genet. 2003 Jan;33(1):90-6. Epub 2002 Dec 09.

Hilpert J, Wogensen L, Thykjaer T, Wellner M, Schlichting U, Orntoft TF,
Bachmann S, Nykjaer A, Willnow TE.
Expression profiling confirms the role of endocytic receptor megalin in renal
vitamin D3 metabolism.
Kidney Int. 2002 Nov;62(5):1672-81.

De Vos J, Thykjaer T, Tarte K, Ensslen M, Raynaud P, Requirand G, Pellet F,
Pantesco V, Reme T, Jourdan M, Rossi JF, Orntoft T, Klein B.
Comparison of gene expression profiling between malignant and normal plasma
cells with oligonucleotide arrays.
Oncogene. 2002 Oct 3;21(44):6848-57.

Spicker JS, Wikman F, Lu ML, Cordon-Cardo C, Workman C, Orntoft TF, Brunak
S, Knudsen S.
Neural network predicts sequence of TP53 gene based on DNA chip.
Bioinformatics. 2002 Aug;18(8):1133-4.

Birkenkamp-Demtroder K, Christensen LL, Olesen SH, Frederiksen CM, Laiho P,
Aaltonen LA, Laurberg S, Sorensen FB, Hagemann R, Orntoft TF.
Gene expression in colorectal cancer.
Cancer Res. 2002 Aug 1;62(15):4352-63.

Tarte K, De Vos J, Thykjaer T, Zhan F, Fiol G, Costes V, Reme T, Legouffe
E, Rossi JF, Shaughnessy J Jr, Orntoft TF, Klein B.
Generation of polyclonal plasmablasts from peripheral blood B cells: a normal
counterpart of malignant plasmablasts.
Blood. 2002 Aug 15;100(4):1113-22.

Orntoft TF, Thykjaer T, Waldman FM, Wolf H, Celis JE.
Genome-wide study of gene copy numbers, transcripts, and protein levels in
pairs of non-invasive and invasive human transitional cell carcinomas.
Mol Cell Proteomics. 2002 Jan;1(1):37-45.

Flamez D, Berger V, Kruhoffer M, Orntoft T, Pipeleers D, Schuit FC.
Critical role for cataplerosis via citrate in glucose-regulated insulin
release.
Diabetes. 2002 Jul;51(7):2018-24.

Vermijlen D, Luo D, Kruhoffer M, Orntoft TF, Kuppen PJ, Wisse E.
Is the presence of interleukin-2 receptor alpha in the serum of colorectal
liver metastases patients derived from hepatic natural killer cells?
Cancer Immunol Immunother. 2002 Jul;51(5):291-2. Epub 2002 May 01. No abstract
available.

Kennan A, Aherne A, Palfi A, Humphries M, McKee A, Stitt A, Simpson DA,
Demtroder K, Orntoft T, Ayuso C, Kenna PF, Farrar GJ, Humphries P.
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa
(RP10) revealed following comparative microarray analysis of transcripts derived
from retinas of wild-type and Rho(-/-) mice. Hum Mol Genet. 2002 Mar 1;11(5):547-57.

Liang G, Gonzales FA, Jones PA, Orntoft TF, Thykjaer T.
Analysis of gene induction in human fibroblasts and bladder cancer cells
exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.
Cancer Res. 2002 Feb 15;62(4):961-6.

Primdahl H, Wikman FP, von der Maase H, Zhou XG, Wolf H, Orntoft TF.
Allelic imbalances in human bladder cancer: genome-wide detection with
high-density single-nucleotide polymorphism arrays.
J Natl Cancer Inst. 2002 Feb 6;94(3):216-23.

Lu ML, Wikman F, Orntoft TF, Charytonowicz E, Rabbani F, Zhang Z, Dalbagni
G, Pohar KS, Yu G, Cordon-Cardo C.
Impact of alterations affecting the p53 pathway in bladder cancer on clinical
outcome, assessed by conventional and array-based methods.
Clin Cancer Res. 2002 Jan;8(1):171-9.

Pedersen MW, Thykjaer T, Orntoft TF, Damstrup L, Poulsen HS.
Profile of differentially expressed genes mediated by the type III epidermal
growth factor receptor mutation expressed in a small-cell lung cancer cell line.
Br J Cancer. 2001 Oct 19;85(8):1211-8.

Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft
T, Eizirik DL.
A comprehensive analysis of cytokine-induced and nuclear factor-kappa
B-dependent genes in primary rat pancreatic beta-cells.
J Biol Chem. 2001 Dec 28;276(52):48879-86. Epub 2001 Oct 30.

Xiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF, Hermansen K.
The effect of chronic exposure to fatty acids on gene expression in clonal
insulin-producing cells: studies using high density oligonucleotide microarray.
Endocrinology. 2001 Nov;142(11):4777-84.

Wyttenbach A, Swartz J, Kita H, Thykjaer T, Carmichael J, Bradley J, Brown
R, Maxwell M, Schapira A, Orntoft TF, Kato K, Rubinsztein DC.
Polyglutamine expansions cause decreased CRE-mediated transcription and early
gene expression changes prior to cell death in an inducible cell model of
Huntington's disease.
Hum Mol Genet. 2001 Aug 15;10(17):1829-45.

Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL.
Identification of novel cytokine-induced genes in pancreatic beta-cells by
high-density oligonucleotide arrays.
Diabetes. 2001 May;50(5):909-20.

Thykjaer T, Workman C, Kruhoffer M, Demtroder K, Wolf H, Andersen LD,
Frederiksen CM, Knudsen S, Orntoft TF.
Identification of gene expression patterns in superficial and invasive human
bladder cancer.
Cancer Res. 2001 Mar 15;61(6):2492-9.

Wikman FP, Lu ML, Thykjaer T, Olesen SH, Andersen LD, Cordon-Cardo C,
Orntoft TF.
Evaluation of the performance of a p53 sequencing microarray chip using 140
previously sequenced bladder tumor samples.
Clin Chem. 2000 Oct;46(10):1555-61.

Celis JE, Kruhoffer M, Gromova I, Frederiksen C, Ostergaard M, Thykjaer T,
Gromov P, Yu J, Palsdottir H, Magnusson N, Orntoft TF.
Gene expression profiling: monitoring transcription and translation products
using DNA microarrays and proteomics.
FEBS Lett. 2000 Aug 25;480(1):2-16. Review